Tangential Flow Filtration

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Tangential Flow Filtration: As one of the most dynamic high-tech industries in the world today, the biopharmaceutical industry is driving the rapid development of global health with its innovative scientific and technological strength and far-reaching medical impact. However, the high purity and high activity requirements of biological drugs make separation and purification technology a key factor restricting the development of the industry. In this context, tangential flow filtration technology, with its high efficiency and economic characteristics, provides strong technical support for the separation and purification links in the biopharmaceutical process, and has become an important force in promoting continuous innovation and optimization of the biopharmaceutical industry.

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Customer Demand

In tangential flow filtration applications, peristaltic pumps are typically used alongside filters to drive the solution through the filter for purification, concentration and filtration. Therefore, t

Maintaining biomolecular integrity: The system must preserve the integrity and activity of the biomolecules while pumping the filtrate.

Adjusting flow rate: The initial pumping solution flow rate is 40 mL/min. However, as the concentration increases, the solution density rises. It is necessary to reduce the pump head speed and flow rate based on the pressure gauge readings to prevent the system pressure from exceeding the filter’s capacity.

System reliability: The pumping system must operate reliably without leaks for 3-5 hours continuously, minimizing the loss of gold-conjugated antibodies.

Longer programme

Longer Precision Pump Co., Ltd. offers comprehensive tangential flow filtration solutions tailored to customer needs. The value of these applications is demonstrated in the following areas:

Accurate Flow Control

The flow error of the Longer Pump peristaltic pump is maintained within ±2%, and can be reduced to ±0.5% after calibration. This precise flow control ensures the achievement of the desired concentration effect.
High Reliability Design

Longer Pump peristaltic pumps ensure that there will be no leakage during long-term continuous operation, reducing the loss of high-value biological molecules. The PharMed silicone hose provided by Longer Pump has excellent corrosion resistance and wear resistance, and the service life of the hose is greater than 10,000 hours, which greatly reduces the leakage loss caused by hose damage when transmitting high-value solutions.
Intelligent Flow Regulation

Longer Pump peristaltic pump solution BT600-2J driver + YZ2515X pump head + PharMed 15# hose provides a wide flow range and can be adjusted manually or automatically to meet the concentration needs of different stages and maintain stable system pressure.
Low Shear Force Protection

When Longer Pump peristaltic pumps pump biologically active substances, the low shear force design ensures the integrity and activity of biological molecules, meeting the laboratory's strict requirements for biological molecule protection.

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